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KMID : 0376619920170030165
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Seoul Journal of Psychiatry
1992 Volume.17 No. 3 p.165 ~ p.175
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Effects of Electroconvulsive Shock on Phosphoinositide-specific Phospholipase C in Rat Brain
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이상환
이정균/서판길/유성호/이여한/박주배/김용식
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Abstract
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Electroconvulsive shock(ECS) is a treatment modality effective to various mental disorders, but its mechanism of action has not been known, In order to elucidate the mechanism, the authors investigated the influence of ECS on
phosphoinosi-tide-specific
phospholipase C(PI-PLC) isozymes which are known to play a crucial role in signal transduction system.
After single or repeated ECS(s) to rat brains, PI-PLC.levels were measured by radioimmunoassay at given times in cerebral cortex, hippocampus and corpus striatum.
The authors measured the levels of PI-PLC β₁ and γ₁after 4, 6, 24 and 48 hours from a single ECS. There wre significant increase in PI-PLC β₁ in cerebral cortex and hoppocampus 6 hours later, and in corpus striatum 4 and 24 hours later. The
level
of PI-PLCγ₁showed significant elavation only in cerebral cortex 4 hours later followed by significant decrease 48 hours later, and tendency to increase in hippocampus and corpus striatum.
The authors investigated same variables after 5 days of ECS(1 shock each day). there was no increase in PI-PLCβ1 in cerebral cortex 4, 6, and 24 hours later. The level of PI-PLC γ1 decreased 4 hours later and increased 24 hours later. ECS of 7
days(1
shock each day) brought about significant increase in PI-PLC β1but no increase in PI-PLCγ1
However, the changes of PI-PLC amounts were around 10-20% with ECS compared to the controls, therefore, it is difficult to asy whether thewe changes have any biological meanings. Flurther studies, including functional assays seem to be necessary.
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